Topical Spironolactone blocks androgen receptors and can be used to target hormonal acne and hair loss in women.

Spironolactone is a prescription only oral or topical medication in the UK traditionally used as a diuretic and to treat high blood pressure. However, it is also a common treatment for some forms of acne and hair loss. Spironolactone works by blocking androgen receptors, thereby reducing the effect of hormones that can lead to acne and hair loss.

Benefits in Skincare

Topical Spironolactone, like oral, inhibits androgen hormones which play a significant role in the development of acne and hair loss. Through this action it reduces oil production in the skin, which helps to prevent clogged pores and breakouts. In the case of hair loss, reducing androgen levels helps to decrease hair thinning and promote hair regrowth. As such, the androgen blocking effects of topical Spironolactone can provide several benefits:

  • Clears Hormonal Acne & Associated Inflammatory
  • Balances Oil Production
  • Reduces Hair Loss
Infographic on topical Spironolactone for acne and hair loss personalised prescription strength treatments in the UK

Treatments with Spironolactone

No two patients are the same so we personalise each and every one of our treatments. For this reason, when designing your treatment, your doctor take into account your concerns, goals and wishes. We use topical Spironolactone in combination with other ingredients if we feel it will be beneficial and appropriate for the patient. Below are the personalised prescription treatments we may use Spironolactone in:

  • Acne
  • Hair Loss

Topical Spironolactone Prescription Treatments in the UK

For obvious reasons all forms of Spironolactone including topical treatments are available by prescription only. Generally, oral Spironolactone is the most common form for treating hormonal acne and hair loss. It is particularly effective for widespread acne and more severe cases of hair thinning but carries greater risks and side effects. On the other hand, you apply topical Spironolactone directly to the skin or scalp. It can target specific areas of concern and if used appropriately should lead to fewer side effects than systemic treatment.

We sometimes add spironolactone to our personalised acne and hair loss treatments if we think it is appropriate and safe for the patient. Regardless, our personalised treatments are available only after an online consultation form or virtual video consultation with one of our doctors. Following this, they will create a bespoke treatment based on what they think will best serve your needs and goals. They’ll also take into account any wishes or preferences you’ve expressed as much as possible. Your doctor will also provide you with a personalised program and follow-up. You will have direct access to your doctor by email at any time throughout your treatment journey.



    Your doctor will design a personalised skincare treatment and program for you to follow. The cost of the consultation will be deducted from any skincare purchase.


    This is a 3 month supply of treatment. The cost depends on the type so please visit our treatment pages for full break down. Your doctor will create a personalised treatment taking into account your health, skin concerns, goals and wishes.


    This is a 3 month supply of treatment (100ml).

Treatment Time Clock

Treatment Time
15 Minutes

Duration of effect calendar

Duration of effect
3-4 Months

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Back to Work
Same Day

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Important Information

Topical Spironolactone is a prescription medicine sometimes used to treat hormonal acne, androgen-related skin issues and hair loss in the UK. Whilst safe in appropriate patients, you must only use this treatment under the care and guidance of a healthcare professional.

Safety and Side Effects

Topical Spironolactone is generally well-tolerated, but it can cause side effects in some individuals. Common side effects include dizziness, breast tenderness and increased urination. In rare cases, it can cause more serious side effects like high potassium levels and changes in menstrual cycles. If you experience severe side effects or allergic reactions, discontinue use and seek medical help.

Combining Spironolactone with Other Ingredients

Spironolactone can be combined with other topical skincare and hair ingredients to enhance its effects. These include Tretinoin, azelaic acid, antibiotics and minoxidil. However, it’s important to avoid combining spironolactone with potassium-sparing diuretics or other medications that can increase potassium levels unless directed by a doctor.


While spironolactone is safe for many individuals, certain conditions may need more caution or avoidance:

  • Hyperkalemia: Individuals with high potassium levels should avoid using spironolactone.
  • Kidney or Liver Disease: Spironolactone can affect kidney and liver function, so it should be used with caution in patients with these conditions.
  • Pregnancy and Breastfeeding: Spironolactone is not recommended during pregnancy or breastfeeding due to potential risks to the baby.

Storage and Shelf Life

Store spironolactone in a cool, dry place, away from direct sunlight and heat. Always check the expiration date on the product packaging and discard any medication that has changed in appearance or smell.

Frequently asked questions

I'm afraid not. Your doctor will only create a treatment they feel are safe and appropriate for you. Whilst we encourage all our patients to express their wishes and concerns when we design their treatment, we will only be able to accommodate these as long as we feel it is medically safe and beneficial to do so. Currently we only use Spironolactone alongside other ingredients as we don't feel it is enough to produce most of the concerns we address.

All our treatments are compound formulas made individually for each patient and should to be used over 3 months from when they're dispensed. Its important to use exactly as directed in your treatment plan.

we only offer our treatments after a consultation with a doctor. This ensures that the treatment is safe for you to use and that it meets your treatment goals. Your doctor will also be able to answer any questions you have and provide you with a personalised treatment plan so you get the most out of your treatment and avoid irritation or side-effects.

Yes. We provide two ways to access our doctors. You can either fill in an online consultation form or book an online video appointment. Please feel free to choose the option that is most convenient for you. Regardless of which consultation type you choose, you will have a single dedicated doctor throughout your treatment journey. They will create a personalised treatment protocol for your and provide ongoing aftercare and advice.

You will have direct access to your doctor by email so you can ask questions, get advice and let them know if you have any problems.

No, you just need to reach out to your doctor by email and they will help you.

We do not charge for any follow up or aftercare. You can contact your doctor at any time for advice, updates and any issues.

No, you can just email your doctor and they will assist you.

No it is not. We are really passionate about putting you in control of your treatment. Everyone responds differently to their treatment so we don't think subscriptions make sense for a personalised journey. That's why we leave it up to you to let us know when you need a refill and we make it very easy to order these.

Unfortunately no.

Your product(s) will be delivered straight to your home. It usually takes 2-3 business days for products to arrive.

No! All our prices are as listed on the website. The fees also include delivery.


Compounded treatments like the ones we use are unlicensed medications because they are custom-made for each patient based on a specific formulation tailored to their unique needs. Unlike licensed medications, which are approved by regulatory bodies for general use, compounded treatments are created by pharmacists to meet the specific requirements of an individual patient as prescribed by their doctor. While they do not undergo the same approval process as licensed medications, they offer a personalised approach that can address specific concerns where a licensed treatment doesn't exist effectively under professional supervision.