Tranexamic acid

​Tranexamic acid is a synthetic derivative of the amino acid lysine and was originally used in medicine to control bleeding. It can also inhibit melanin production. As such, it has a long history of use in dermatology to fade dark spots and even out skin tone. Tranexamic acid is available as topical cream or serum treatments for melasma and uneven pigmentation in the UK. It is also available as an oral medication by prescription only.

Benefits in Skincare

Tranexamic acid helps to reduce skin discolouration and fade pigmentation by interrupting the skin’s pigment production pathways. This suppresses excess melanin production. The key benefits of topical tranexamic acid for skin include:

• Melasma & Hyperpigmentation Treatment: Tranexamic acid has shown promise in improving the appearance of melasma. It can also help fade sun spots and post-inflammatory hyperpigmentation.
• Skin Brightening: Regular use leads to a brighter and more even skin tone.
• Anti-inflammatory: Tranexamic acid’s ability to reduce skin inflammation contributes to its effectiveness in treating pigmentation disorders. It may also help reduce redness.

Treatments with Tranexamic Acid

We design every one of our personalised skin treatments according to each of our patient’s skin concerns, goals and wishes. Our doctors add tranexamic acid to the following personalised prescription strength skincare treatments if they think it will be beneficial:

• Melasma
• Acne marks
• Hyperpigmentation
• Glowing Glass Skin

Tranexamic Acid Treatment in the UK

In the UK, tranexamic acid is available over the counter to treat pigmenattion disorders like melasma in a range of topical formulations including creams, serums and gels. It is also available by prescription only as an oral treatment for melasma. At City Skin Clinic, our doctors may use tranexamic acid in our personalised prescription skincare creams for melasma and uneven pigmentation if they think it is suitable. This is usually alongside other actives such as tretinoin, azelaic acid or hydroquinone depending on the patient’s needs. The concentration of tranexamic acid and the combination of other ingredients in your custom melasma cream will be tailored to your skin type, concerns and goals.

To access our personalised skin treatments, you’ll need to complete our online consultation form or book a virtual video consultation with one of our doctors. Your doctor will design a treatment based on your needs and where possible take into account your preferences. You’ll receive a detailed skincare routine and ongoing support including regular reviews and the ability to email your doctor at any time as part of your treatment journey.

Important Information

Tranexamic acid is suitable for a variety of skin types and is increasingly available in topical skincare products such as serums and creams in the UK. While it is a well-tolerated and effective ingredient for managing melasma and pigmentation, it’s important to understand its potential risks and safety considerations.

Combining Tranexamic Acid with Other Ingredients

Tranexamic acid can be safely used alongside several other active ingredients, including niacinamide, azelaic acid, vitamin C and kojic acid to enhance its effects. However, if you’re layering it with strong exfoliants or retinoids, extra care is necessary. This is especially crucial if you have sensitive or reactive skin conditions like rosacea.

Contraindications

People with a known allergy to tranexamic acid or any component in a formulation should avoid using products containing it. As with any active skincare ingredient, consult with your healthcare provider before using topical tranexamic acid if you are pregnant, breastfeeding or have any pre-existing skin conditions.

Safety and Side Effects

Topical tranexamic acid is generally well tolerated, but some individuals may experience mild irritation, redness, dryness or flaking. Risks are most likely when first starting treatment or if using high concentrations. Side effects are usually temporary and improve with continued use or adjustment of application frequency. There is also the more serious risk of allergic reaction or over lightening the skin. Discontinue use and seek medical advice if you experience any severe or persistent reactions.

Storage and Shelf Life

Store tranexamic acid products in a cool dry place away from direct sunlight and heat to maintain their stability and effectiveness. Always check the expiration date on the packaging and avoid using any product that has changed in colour, consistency or smell.