Obagi Nu-Derm System (Prescription only)

Obagi Nu Derm is a Complete skin care system specially formulated for normal to dry skin to help correct hyperpigmentation, such as dark spots and melasma, and transform the appearance of aging skin.

Obagi Nu Derm System Online UK

Obagi Nu-Derm is a complete skincare system that is available in the UK in two forms (Fx and Rx). It is an advanced system designed to work on all skin types and tones. The Obagi Nu-Derm skin transformation system helps to correct hyperpigmentation, dark spots, melasma, smooth texture and treat the appearance of aging skin.

The Kit Includes:

Revolutionise your skincare routine with the Obagi Nu-Derm System. This pioneering skincare solution is meticulously crafted for those who demand the best for their skin. Please note you will need a consultation with one of our doctors to assess you and ensure that the Obagi Nu-Derm system is the correct system for you.

Obagi Nu-Derm System Transforms Your Skin From the Inside Out

The Obagi Nu-Derm System helps transform your skin’s appearance. This Dermatologist recommended treatment works by evening out skin tone, smoothing texture, and treating wrinkles. The end result is younger and healthier-looking skin. Nu-Derm is ideal if you have:

  • Age spots
  • Fine lines and wrinkles
  • Rough skin
  • Erythema (redness)
  • Sallowness (yellowish complexion)
  • Melasma or hyperpigmentation (discolouration)

The system is available for either normal-dry or normal-oily skin. It comes in two variants. The Nu-Derm Rx (POM) is available by prescription only because it contains 4% Hydroquinone. The Nu-Derm Fx system is available over the counter and contains Arbutin. Please note, regardless of the system you will need a virtual consultation with one of our doctors before starting either of the Obagi Nu-Derm systems through our online clinic. They will ensure that you are using the best system for your skin, personalise your protocol and provide free follow up throughout your journey.

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What’s the Difference Between the Obagi Nu-Derm Rx (POM) and Nu-Derm Fx Systems?

The main difference between the Obagi Nu-Derm Rx (POM) and Fx system is it contains 4% hydroquinone. This means that the Nu-Derm Rx (POM) is a prescription only system in the UK. You can treat the same skin concerns with both systems. However, the more potent hydroquinone found in the prescription system may work better in severe hyperpigmentation and for more pigmented skin tones.

Patients who use the prescription system typically start to see progress in as little as 6-8 weeks. The Nu-Derm Fx system contains arbutin, which is gentler and so more suitable for sensitive skin. As such, it can take as much as 24 weeks to see noticeable results. Your doctor can advise you on which system would suit your needs best during your consultation. Please note you must have a consultation with one of our doctors who will discuss which treatment be best for you and put together a personalised treatment protocol. 



    Our expert doctor will design a bespoke Obagi Skincare program for you to follow. The cost of the consultation will be deducted from any skincare purchase.


Treatment Time Clock

Treatment Time
15 Minutes

Duration of effect calendar

Duration of effect
3-4 Months

Back to work briefcase

Back to Work
Same Day

Where Can I Get Obagi Nu-Derm System in the UK?

There are a couple of ways you can get Obagi Nu-Derm in the UK depending on what type of treatment you need. At City Skin Clinic, we’ve simplified this procedure. Through our online clinic, you can access Obagi Nu-Derm treatments in the UK from the comfort of your home. All you need to do is complete our online consultation form or book a virtual consultation. Your doctor will then create a personalised treatment protocol to address your skin concerns and goals. Treatments will be delivered to your home and your doctor will then monitor your progress throughout your entire journey.

You can also get this treatment through a bricks and mortar aesthetic clinic. Here, after a review, they can advise whether you should use the Fx or Rx system and order it for you. Since the Obagi Nu-Derm Rx (POM) system is prescription only, this consultation would have to be done by a doctor, dentist or nurse prescriber. You would then need to attend follow ups in clinic for them to monitor your treatment. It is possible to directly buy the Obagi Nu-Derm Fx system as this is not a prescription product. You can do this through a number of medical spas as well as online. However, you should check that they are authorised to sell Obagi products since there are many counterfeit products on the market.

How Should You Use the System?

Every one’s skin is different. We believe that you can get the best results out of the Obagi Nu-Derm system through a personalised treatment protocol. This not only allows you to reduce the risk of irritation when you start the treatment but our doctor will adapt your protocol over time to adjust to how your skin responds. From experience, we also know that some people can get significant benefits of integrating a retinoid like Retinol or Tretinoin into this protocol. These accelerate skin cell turnover and boost collagen production. Retinoids work synergistically with the Nu-Derm system to fade hyperpigmentation and reduce visible signs of ageing like skin laxity and fine lines. Used together they can also improve your overall skin health and radiance. Retinoids will also help build on your results and maintain them once you have finished your Nu-Derm treatment.

Frequently asked questions

This depends on the severity of your skin concern. Most people will need to use the Nu-Derm system for 12-18 weeks. We do not recommend using Nu-Derm Rx(POM) for more than 24 weeks at a time but you can use the Fx system for longer.

If used correctly, the products can last for the whole treatment period if treating moderate concerns on the face and neck. If you need a more aggressive protocol or also want to treat the chest area, then you may need to purchase Clear Rx after 8 weeks.

While individual experiences may vary, many users start to notice visible improvements in as little as 4-6 weeks especially if used with a retinoid like Tretinoin. However you will need to use it for longer to build up and maintain the results.

Whilst the Obagi Nu-Derm System is safe to use, we do not recommend using the Rx hydroquinone containing products for more than 24 weeks consecutively. However, you can take a break of 2-3 months and restart it if you need to build on your results. The Nu-Derm Fx is safe to use in the long term. However, we don't think you need to use the whole system once you get your results. Our doctors will help design a protocol for you to use following your treatment. This can include over the counter products that you have used in the past or items from the Obagi range if you prefer.

Yes it is possible to use this system if you have sensitive skin but your doctor will design your protocol to reduce the risk of irritation.

At the beginning we don't recommend anything other than a retinoid as we want to get your skin to adjust to the system. However, as you move along your treatment journey your doctor can update your protocol to include any skincare products like hydrating serums, masks, LED devices or Vitamin C that you normally use.

You will need to book a virtual video consultation or use our online consultation form. Your doctor will then check if this treatment is suitable for you and provide you with a personalised protocol.

We can only offer our treatments after a consultation with a doctor. This ensures that the treatment is safe for you to use and that it meets your treatment goals. Your doctor will also be able to answer any questions you have and provide you with a personalised treatment plan so you get the most out of your treatment and avoid irritation or side-effects.

Yes. We offer either online consultation forms or video appointments. Whatever option you choose, you will have the same doctor dedicated to you throughout your treatment and get a personalised experience.

Yes, you will need a consultation if you are a new client to our online skin clinic.

You will have direct access to your doctor by email at all times. You can ask questions, get advice and let them know if you have any problems.

No, you just need to reach out to your doctor by email and they will help you. This maybe by email or a virtual video follow up depending on the problem.

Nope! We never charge for any follow up or aftercare. You can contact your doctor at any time for advice, updates and questions.

No, you can just email your doctor and they will assist you. You will be able to purchase individual items if they run out of them.

Unfortunately we can only offer our services to people who are 18 years old and over who are based in the UK.

Once you've settled your treatment invoice, your product(s) will be delivered straight to your home. It usually takes 2-3 business days for products to arrive.

Nope! All our treatment fees are as listed on the website. This also includes delivery.


Safety Guidelines for Obagi Nu-Derm Rx System – Clear & Blender (containing 4% hydroquinone)

People who’ve previously exhibited sensitivity or allergic responses to this formulation or any of its components should not use it. In addition, the suitability of hydroquinone in pregnancy, breastfeeding or children under the age of 12 remains unconfirmed. Hence should not be used in these individuals either.

Critical Alerts:

  • Avoid direct contact with the eyes, nose, mouth or lips should. If unintended contact occurs, immediately rinse the affected area with water and seek medical advice.
  • Consistent sunscreen application is vital during hydroquinone treatment. This is due to the heightened melanocyte activity with even minimal sun exposure.
  • This system contains sodium metabisulfite. This is a type of sulfite that can lead to allergic reactions. These might range from severe anaphylactic symptoms to milder asthmatic episodes. This reaction is more prevalent in individuals with asthma, although its overall occurrence in the population is likely rare.

Precautionary Measures (see Critical Alerts too):

It’s recommended to apply the treatment to limited skin areas initially. This is because certain users have reported temporary skin redness and a slight burning sensation. However, such reactions don’t necessarily indicate the need to halt treatment.

Potential Risks & Side-Effects:

While the Obagi Nu-Derm Rx (POM) System offers transformative results for many, it’s essential to be aware of potential side effects. Inappropriate or extended use, especially without proper guidance, can lead to complications. This includes rebound hyperpigmentation, where the skin darkens beyond its original tone post-treatment. Additionally, there’s a risk of ochronosis, a rare side effect of hydroquinone that manifests as bluish-black discolouration on the skin. It’s crucial to adhere to your treatment protocol as your doctor will design it to reduce these risks.

Start Your Online Consultation

The journey to great skin starts here. Start your online consultation for personalised prescription-strength skincare.

Start Consultation