Peptides have gotten a lot of attention in the world of skincare and chief amongst them is Matrixyl stands out! This is a powerful ingredient with a whole host of alleged impressive benefits for skin. Matrixyl is particularly popular in anti-ageing and skin firming products. However, as always how much of this is real vs good marketing? We’re going to dive into the science behind Matrixyl’s benefits for skin, side effects and how to use it in skincare. We’ll also explore the different peptide forms including Matrixyl 3000 and Synthe’6 to help you decide which is best for your skin.
What is Matrixyl?
Matrixyl is a synthetic peptide developed by the biotechnology company Sederma in the early 2000s. Initially, researchers were exploring peptide-based ingredients for their potential to promote skin healing and regeneration. In particular because of their role in cellular communication and wound repair. Matrixyl is part of a broader category of “matrikine” peptides. These are compounds that can signal skin cells to begin repair themselves. The reason it stood out was that it was capable of stimulating collagen and other extracellular matrix components. This discovery was significant because collagen plays a central role in maintaining the skin’s structure, firmness and elasticity. Additionally its natural decline is a primary factor in visible ageing.
How Does it Work?
The main mechanism by which Matrixyl works is encouraging the skin to rebuild itself from within. Matrixyl peptides work by mimicking the skin’s natural peptides involved in collagen synthesis and skin repair. When applied topically, these peptides penetrate the skin’s outer layer (stratum corneum) and reach the dermis. This is where collagen and elastin fibres are formed. Once there, they stimulate fibroblast cells, they prompt them to produce more collagen and elastin. These are the two essential proteins that help skin maintain its firmness and resilience.
There are now a number of different types of Matrixyl peptides. However, the original Matrixyl peptide, also known as palmitoyl pentapeptide-4, was what kicked it all off. In multiple studies it has been shown to increase collagen synthesis, helping to plump the skin and reduce the appearance of wrinkles and fine lines. These days, there are also newer forms such as Matrixyl 3000 and other advanced formulations. These seek to magnify benefits like reducing inflammation, slowing down collagen degradation and boosting collagen production. We will discuss the different types and how to choose the best one for you later in this article.
Benefits of Matrixyl Peptides for Skin
In the simplest way possible, Matrixyl peptides stimulate your skin cells to regenerate and repair. This has a number of benefits in terms of skin health and healing. The top benefits of using Matrixyl peptides for the skin include:
- Reduces the Appearance of Fine Lines & Wrinkles: By promoting collagen synthesis, Matrixyl helps to fill in lines to make the skin look smoother and more youthful. Studies have shown that continuous use of Matrixyl-containing products can result in significant wrinkle reduction with some users noticing a difference within weeks.
- Improves Skin Firmness & Elasticity: As we age, collagen and elastin levels decline, causing the skin to sag and lose its firmness. Matrixyl peptides address this by stimulating both collagen and elastin production, which helps to restore the skin’s structural integrity.
- Enhances Skin Hydration: Matrixyl also aids in improving skin hydration. This is because it increases collagen levels which helps the skin retain moisture, making it appear more supple and radiant.
- Promotes Skin Repair & Healing: The ability of Matrixyl to stimulate the skin’s natural repair processes also aids in faster healing and recovery. When combined with soothing ingredients like niacinamide, it can even help reduce the appearance of post-acne marks and minor scars.
- Evens Out Skin Tone: An indirect benefit of Matrixyl is that it can improve and even out skin tone. This is through stimulating skin regeneration which helps repair skin and fade dark spots over time. The skin brightening benefit of Matrixyl is best when used alongside agents like Vitamin C and E.
The Different Types of Matrixyl Peptides
Matrixyl has evolved over time into several formulations each one focusing on a specific set of benefits. The main Matrixyl peptides in skincare at the moment are:
- Matrixyl (palmitoyl pentapeptide-4): This is the original peptide. It remains a popular choice for those looking to improve overall skin firmness and reduce fine lines through increased collagen production.
- Matrixyl 3000: This a combination of two peptides – palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. Matrixyl 3000 was developed to not only stimulate collagen but also to reduce inflammation in the skin. It is especially beneficial for those with mature skin who may experience deeper wrinkles, as the peptides work synergistically to increase collagen and elastin production.
- Matrixyl Synthe’6: Another advanced form, Matrix Synthe’6 targets six essential components in the skin’s matrix. These include collagen, hyaluronic acid and fibronectin. The effect is to promote skin density, smoothness and firmness. This formulation is ideal for those seeking to improve skin plumpness and fullness in addition to reducing wrinkles.
- Matrixyl Morphomics: This is a newer addition to the Matrixyl family and specifically targets vertical wrinkles like frown lines by improving cellular communication within the skin. This formulation is best for individuals concerned with more dynamic facial lines and those who wish to achieve a more relaxed, youthful expression.
How to Choose the Best Type of Matrixyl for Your Skin
Although there is a lot of overlap between the overall actions of all the mtrixyl peptides, there are some differences which might make some better than others for you. As a general rule the best Matrixyl type depends on your specific skin concerns and goals:
- For general anti-ageing & first signs of wrinkles: The original Matrixyl (palmitoyl pentapeptide-4) is a reliable option for improving overall skin firmness and elasticity. It’s ideal for those who are beginning an anti-ageing routine or have mild to moderate signs of ageing.
- For deep wrinkles & mature skin: Matrixyl 3000, with its dual peptide formula, is ideal for addressing more pronounced wrinkles and sagging. This formula is particularly beneficial for mature skin that requires greater collagen and elastin support.
- For skin density, smoothness & plumpness: If your primary goal is to increase skin thickness and fullness, Matrixyl Synthe’6 might support a broader range of skin matrix components. This option is great if you have thinning skin.
- For vertical lines & dynamic wrinkles: Matrixyl Morphomic focuses on vertical lines, such as frown lines and marionette lines. It’s the best choice for those who want to address expression lines or wrinkles that result from facial movements.
Best Way to Use Matrixyl in Your Skincare Routine
The great news is that it is super easy to add Matrixyl to your skincare routine. It is versatile, generally well tolerated by most skin types and you can layer it with other skincare ingredients. Here are our tips for how to use Matrixyl in your skincare routine:
- Start with a Good Cleaning: Cleanse your face with a gentle product to remove impurities. This helps prep your skin to absorb active ingredients.
- Use as a Serum or Moisturiser: After cleansing and toning, apply a Matrixyl-based serum or light-weight moisturiser. Serums tend to have a higher concentration of active ingredients and may deliver more noticeable results.
- Layer with Hydrators: Matrixyl pairs well with hyaluronic acid and other humectants. Consider layering a hydrating serum or moisturiser after your Matrixyl product to lock in moisture and enhance skin plumpness.
- Use with Sunscreen: Since Matrixyl works to repair and protect the skin it makes no sense to then expose the skin to sun damage. Use a high-SPF sunscreen during the day to protect your skin against UV damage, which can accelerate ageing.
- Combine with Actives: Matrixyl can also be layered with irritating active skincare ingredients as it helps to soothe and repair the skin. Use it after applying your Retinoid, Vitamin C or exfoliating acid to help reduce any potential irritation.
Side Effects & Precautions
Matrixyl and its derivatives, including Matrixyl 3000, Matrixyl Synthe’6, and Matrixyl Morphomics, are generally well-tolerated and suitable for sensitive skin. However, as with any new skincare ingredient, it’s wise to conduct a patch test before applying it to the entire face. For optimal results, consistency is key, and it’s recommended to use it for several weeks to notice visible improvements in skin firmness and smoothness.
Matrixyl peptides have become skincare favourites for good reason! These are scientifically backed effective ingredients that deliver visible improvements in skin firmness, hydration and wrinkle reduction. Each form of Matrixyl – from the original to Matrixyl 3000, Synthe’6, and Morphomics – offers unique benefits tailored to specific skin concerns. Using the right type of Matrixyl in your daily skincare routine can provide a noticeable boost in skin texture, quality and tone. As ever, consistency and patience are key. With time and in the context of a good skincare routine, it is possible to reap its benefits for your skin.
At City Skin Clinic, we are super passionate about personalised skincare. We offer safe and effective compound skincare treatments with prescription-strength ingredients. These include Tretinoin and Hydroquinone where appropriate through online skin clinic. Our doctors treat a range of conditions such as acne and scars, hyperpigmentation, melasma, skin ageing. To start your personalised skincare plan, book a virtual video consultation or use our online consultation form. The journey towards great skin starts here.
